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A second phase of trials, involving two hundred and forty patients, was near completion.Gilman had chaired the safety-monitoring committee for the trials.Cohen had accumulated hundreds of millions of dollars’ worth of Elan and Wyeth stock. Sid Gilman’s presentation of the clinical data in Chicago was a classic catalyst: if the results were promising, the stocks would soar, and Cohen would make a fortune. Seventy-six years old and suffering from lymphoma, he had recently undergone chemotherapy, which left him completely bald—like the “evil scientist in an Indiana Jones movie,” he joked. He was a revered figure in medical circles, the longtime chair of neurology at the University of Michigan’s medical school. But soon after Gilman began his thirteen-minute presentation, accompanied by Power Point slides, it became clear that the bapi trials had not been an unqualified success.In Ann Arbor, a lecture series and a wing of the university hospital were named for him. Bapi appeared to reduce symptoms in some patients but not in others.Gilman was “incredibly supportive” of younger faculty, Young said. G., as it was known, served as a matchmaker between investors and experts in specialized industries who might answer their questions. when it would certainly pay,” the company’s chief executive, Mark Gerson, told the . Gilman was hardly alone in saying yes to such a proposal. Its headquarters, on a spit of land in Stamford, Connecticut, overlooking the Long Island Sound, are decorated with art from Cohen’s personal collection, including “Self,” a refrigerated glass cube, by Marc Quinn, containing a disembodied head sculpted from the artist’s frozen blood. As Cohen sat at his sprawling desk, before a flotilla of flat-screen monitors, and barked orders for his personal trades, a camera—the “Steve cam”—was trained on him, broadcasting his staccato patter to his subordinates. “He was ambitious—he wanted to make something of his life,” Ronald Green, who supervised Martoma during his year at N. She had grown up in a sheltered family and had never dated before.“He would go over grants with us, really putting an effort into it, which is something chairs rarely do.”One day in 2002, Gilman was contacted by a doctor named Edward Shin, who worked for a new company called the Gerson Lehrman Group. “It was kind of ridiculous that the hedge-fund business got so much information by asking for favors . A study published in the found that, by 2005, nearly ten per cent of the physicians in the U. had established relationships with the investment industry—a seventy-five-fold increase since 1996. It was nearly as frigid on the twenty-thousand-square-foot trading floor, which Cohen kept fiercely air-conditioned—employees were issued fleece jackets with the S. Cohen is not a physically imposing man: he is pale and gnomish, with a crooked, gap-toothed smile. But she felt an immediate bond with Mathew: her parents were also from Kerala, and she, too, felt both very Indian and very Western.One market analyst, summarizing the general feeling, pronounced the results “a disaster.” The Chicago conference was indeed a catalyst, but not the type that investors had expected. and teaching at Harvard and Columbia, Gilman was recruited to run the neurology department at the University of Michigan. officers who could monitor the public statements of corporate executives and evaluate whether they were hiding something; S. From his first days in Stamford, he was interested in the investment potential of bapi. But Sid Gilman accepted, noting, in his response to G. G., that he would “share only information that is openly available.” On the Sunday after the initial conversation with Gilman, Martoma sent an e-mail to Steven Cohen, suggesting that S. His parents had emigrated from Kerala, in southern India, during the sixties.

“These stocks, they’re your babies, and you’re following them and you’re nurturing them.” The fixation became a running joke, and her conversations with him were often punctuated by the word “Bapsolutely!

“He was not a flashy guy who revelled in expensive toys,” Tim Greenamyre, a former student, who now runs the Pittsburgh Institute for Neurodegenerative Diseases, told me. They spoke about Alzheimer’s remedies, and specifically about bapineuzumab. “Mathew didn’t just do that job by himself,” she told me, with a smile. “It was heads-down, tails-up, twenty-four-seven kind of work.” Martoma rose at 4 .

Gilman counselled Greenamyre and other colleagues to avoid even the appearance of a conflict of interest in their professional dealings, and he made a point of telling people that he never invested in pharmaceutical stocks. Although Martoma had no medical background, he was attuned to the scientific intricacies at play. to keep up with the European health-care markets, then worked until the market in New York closed.

The article noted that the speed and the extent of this intertwining were “likely unprecedented in the history of professional-industrial relationships.”Gilman read the article, but disagreed that such arrangements were objectionable. “I was just enamored with how lovely he was,” she told me recently.

In an e-mail to Shin, he explained that investors often offered him a fresh perspective on his own research: “Although remuneration provides an incentive, the most attractive feature to this relationship (at least for me) is the exchange.”Gilman’s university salary was about three hundred and twenty thousand dollars a year, a sum that went a long way in Ann Arbor. “And he seemed to be very respectful of my parents.” Her mother and father endorsed the relationship, and in 2003 Mathew and Rosemary were married, in an Eastern Orthodox cathedral in Coral Gables, Florida.

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