The most common cause of non-healing is spasming of the internal anal sphincter muscle which results in impaired blood supply to the anal mucosa.
The result is a non-healing ulcer, which may become infected by fecal bacteria.
If acute they may cause pain after defecation, but with chronic fissures, pain intensity is often less.
Anal fissures usually extend from the anal opening and are usually located posteriorly in the midline, probably because of the relatively unsupported nature and poor perfusion of the anal wall in that location.
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You may report side effects to FDA at 1-800-FDA-1088. Please also see the Patient Information within the full Prescribing Information.
Anal incontinence can include inability to control gas, mild fecal soiling, or loss of solid stool.
Some degree of incontinence can occur in up to 45 percent of patients in the immediate surgical recovery period.
However, some anal fissures become chronic and deep and will not heal.Examples of sexually transmitted infections that may affect the anorectal area are syphilis, herpes, chlamydia and human papilloma virus.In infants, frequent diaper change can prevent anal fissure.Fissure depth may be superficial or sometimes down to the underlying sphincter muscle.Most anal fissures are caused by stretching of the anal mucosa beyond its capability.