870 single adult
Correlate the polymorphism A870G of CCND1 to the risk of colorectal cancer (CRC), to environmental risk factors and clinical aspects in Brazilian patients.
One hundred twenty-three Brazilian patients with colorectal cancer were matched by age and sex to 120 healthy individuals.
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There was no difference in the frequency of the alleles A (43.8% versus 43.9%) and G (56.3% versus 56.1%) in the groups.
Cyclin D1 (CCND1) is a regulatory protein involved in the cell cycle.
A common G to A polymorphism in the CCND1 gene is implicated on the splicing of the CCND1 transcript, and this protein may be associated to a deregulated cell proliferation.
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